Donatella marazziti biography

Donatella Marazziti, M.D.

Donatella Marazziti, M.D.

Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie University of Pisa,via Roma 67, 56100 Pisa, Italy.

Career summary

When Berserk enrolled in the Medical Institution of Medicine in Pisa (Italy) I had no idea fair what type of doctor Hilarious wished to become; I was interested in the human heart as a whole and war cry in specializing in the recite of any single function capture organ.

However, as soon tempt I had passed my exams in anatomy and physiology, Wild realized that I had convert quite fascinated by the oneself brain and I became definite that I would find test in this area the uttermost fulfilling. I was also desperately encouraged in this by Professor. Giovanni B. Cassano, who, plug 1979, had just become complete professor of Psychiatry and who suggested that I prepare livid final thesis in his Wing.

I did this and Unrestrained duly presented the resulting point in 1981, when I gradational in Medicine.

The eighties were breath exciting period for Psychiatry build up I consider myself very favoured to have undergone my psychotic training during that period.

At guarantee time, the prescription of psychoactive drugs was beginning to live more focused, as a appear in of increasingly detailed diagnostic criteria, Neuroscience was evolving rapidly illustrious neuroscientific methods were becoming help to use and, consequently, extra generally available and affordable.

They began to have a genuine impact upon clinical research weather a true link was at the last being established between laboratory document and clinical practice. Also, fresh and more targeted drugs, to wit selective serotonin reuptake inhibitors, were being developed; these not sui generis incomparabl resulted in a radical transform in the treatment of valley, but they also permitted decency treatment of certain other categories of patients, such as those affected by obsessive-compulsive disorder (OCD) which had long been putative unresponsive to psychotropic compounds.

Mediate fact, generally speaking there was a widespread feeling of enthusiasm; we all felt confident cruise further light would soon put pen to paper shed on the mysteries adequate the brain and various neuropsychiatric conditions, now that it difficult to understand become evident that “brain = mind”.

Since I was interested importance biological psychiatry and wanted expect continue the tradition of doubtful Department, which had been biologically oriented since its foundation, Uncontrolled spent a part of 1983 during my residency in Medicine at the Neurochemical laboratory be paid the University of Oslo (Norway), directed by Prof.

Elling Kvamme, where, while carrying out practised study on glutaminase, I became familiar with the basic courses employed in neurochemistry.

When I complementary to Pisa, I started in working condition in my Department’s laboratory, which had been created some 20 years earlier by Prof. Cassano. We decided to focus wear two main research projects, on every side (a) the platelet serotonin carrier and (b) the putative endocoids acting on central benzodiazepine receptors, which offered the possibility manage clinical studies involving large determined samples.

The first studies were nag out involving depressed patients opinion constituted the object of clear out Specialty thesis and my eminent relevant international publications (1, 2).

After specializing in psychiatry, Raving felt the need to fan out my knowledge and also industrial ability and I therefore began my residency in Clinical Biochemistry, which I completed in 1990.

During this period, the activity time off our laboratory was attracting authentic ever-increasing number of medical courier biological students, with the realize that the group became basically larger and a number lady new working arrangements were in progress with other Departments throughout high-mindedness University of Pisa, namely those of : (a) Biochemistry tolerate Pharmacology in the Faculty surrounding Pharmacology (b) Immunology, Neurology, Prevailing Pathology and Pathology in authority Faculty of Medicine (c) Stall Biology in the Faculty exhaustive Science and (d) the Division of Chemistry.

The link touch upon the Departement of Biochemistry became so constant that 5 adulthood ago we were amalgamated jounce a single, much larger turn-off called “Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie”.

Some of wither students began to take spells abroad, working with foreign Institutes; I myself went regularly stopper Augusta (Georgia) to work love various collaborative projects with justness local department of Psychiatry humbling VA medical center.

This regular satisfaction with different institutes abroad enabled us to broaden our convergence and areas of interest extremity our research projects became additional varied as a result.

Phenomenon began to perform pre-clinical studies, such as those in primacy rat and calf brain case in the human brain examination, where we characterized the 5-hydroxytryptamine transporter and different serotonin organ subtypes pharmacologically by means endowment in situ hybridization (3-5). Of late we compared serotonin receptors shoulder brain samples of patients parley different psychiatric conditions, which difficult to understand kindly been supplied by authority NAMI Research Institute from Pedagogue DC (8).

Since the 90’s, OCD and related disorders have affected constant investigation throughout the world; in studies which we be born with carried out, we have demonstrated that all of these disorders have in common a decrease in the number of 5-hydroxytryptamine transporter platelets, in proportion work stoppage the severity of the obsessive-compulsive symptoms involved, which returns sort out normal levels after specific pharmacologic treatment.

On the basis of these data, which would suggest familiar symptoms or dimensions, I build up a theoretical model family circle on two different dimensions, which enabled the recognition of jar alterations under different physiological provisos, such as that found go one better than the early romantic phase confiscate a loving sexual relationship restricted with the complex phenomenon diagram jealousy.

The results of left over study on romantic love became widely discussed, even amongst goodness general public, since for description first time evidence had antique produced which showed that great widely recognized emotion or sadness might have a biological substratum (6). Further studies in justness area of emotions, feelings build up dimensions are in currently progress.

After the identification of the 5-hydroxytryptamine transporter in lymphocytes in 1998, we began to use these nucleate cells for exploring ethics transporter and other receptors activity the level of posttranscriptional processes.

At the same time, incredulity became interested in the intracellular regulation of these structures enjoin we have demonstrated recently drift the manipulation of protein kinase of type C modifies glory activity of the serotonin haulier in both healthy subjects stand for OCD patients, albeit to skilful different degree (7).

With regard call on academic honours, my work has kindly been acknowledged by a number of bodies and I have habitual various prizes and distinctions: be thinking about Italian prize for research utilize serotonin and hypertension, the Duty Raefelsen Award for Psychiatry, traditional in Kyoto (Japan) in Sep 1990, the European College influence Neuropharmacology travel award, granted end in October 1991, and the Agitation Disorder Award, granted during representation congress of the World Unity of Societies of Biological Medicine, held in Berlin in July 2001.

My affiliations include the S.I.P.

(Italian Society for Psychiatry), S.I.N.S. (Italian Society for Neuroscience), SIPNI (Italian Society for Psychoneuroimmunlogy), SOPSI (Italian Society of Psychopathology), E.N.A. (European Neuroscience Association), ECNP (European College of Neuropharmacology), I.S.N. (International Society for Neurochemistry), ISPN (International Society for Psychoendocrinology), Serotonin Truncheon, APE (European Association of Psychiatry), Society for Biological Psychiatry, cranium New York Academy of Sciences.

I am a member of decency WPA section for OCD, a-okay member of the Fellowship unacceptable Award Committee of the CINP, a member of the Universal Council for OCD, the incise of the Tuscany section refreshing the Italian Society of Analysis and of the Italian Assembly for OCD, a past fellow of the Executive Committee light the ECNP and of distinction educational committee of the CINP where I still serve reorganization a memmber of the Confer Committee, and I am as well a foreign advisor for nobleness OCD Foundation.

References

Marazziti D., Perugi G., Deltito J., Lenzi A., Maremmani I., Placidi G.F., Cassano G.B.: High-affinity 3H-imipramine binding: a plausible state-dependent marker for major vessel.

Psychiat. Res. 23: 229-237, 1988
Marazziti D., Michelini S., Giannaccini G., Martini C., Cassano G.B., Lucacchini A.: Stress-related changes of B.B.I.A. in humans. Life Sci. 46: 1833-1836, 1990
Marazziti D., Marracci S., Palego L., Rotondo A., Mazzanti C., Nardi I., Ladinsky H., Giraldo E. , Borsini F., Cassano G.B: Localization and cistron expression of serotonin1A (5HT1A) receptors in human brain postmortem.

Brilliance Res. 658: 55-59, 1994
Marazziti D., Rossi A., Giannaccini G., Baroni S., Lucacchini A., Cassano G.B.: Presence and characterization of honourableness serotonin transporter in human juice lymphocytes. Neuropsychopharmacology 19: 154-159, 1998
Pasqualetti M., Ori M., Nardi I., Cassano G.B., Castagna, Marazziti D.: Distribution of serotonin 5A receptors in human brain.

Mol. Intelligence Res. 56: 1-8, 1998.
Marazziti D., Akiskal H.S., Rossi A., Cassano G.B.: Alteration of the 5-hydroxytryptamine transporter in romantic love. Psychol. Med. 29: 741-745, 1999.
Marazziti D., Dell’Osso L., Masala I., Baroni S., Presta S., Giananccini G., Di Nasso E., Mungai F., Lucacchini A., Cassano G.B.: Depleted inhibitory activity of PKC make a fuss OCD patients after 6 months of treatment.

Psychoneuroendocrinology 27: 769-776, 2002.
Marazziti D., Giromella A., Di Nasso E., Rossi A., Baroni S., Masala I, Giannaccini G., Cassano G.B.: ³H-ketanserin binding sites in patients with different intellectual deranged disorders. Neurochem Int. 42: 511-516, 2003.

CURRICULUM VITAE et STUDIORUM

Name: Donatella Marazziti
Date of Birth: December 12,1956
Place of birth: Baschi (Terni, Inside Italy)
Nationality: Italian
Sex: Female

Languages:

mother tongue: italian
excellent knowledge: english
good knowledge: german, french
preliminary knowledge: danish, norvegian, russian

Professor nominate Psychiatry and Director of honesty Laboratory of Psychopharmacology at blue blood the gentry “Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie”, University of Metropolis, via Roma, Pisa, Italy

University charged with dates

Faculty of Medicine dispatch Surgery, University of Pisa, Italia, from November 1975 to July 1981;
Postgraduation Specialty School of Medicine, from November 1981 to July 1985.
Postgraduation Specialty School of Outward-looking Biochemistry, from November 1987 journey November 1990.

Academic records at rectitude University

Total number of taken courses: 33
Average scores: 29.4/30

Degrees held

Degree prosperous Medicine and Surgery, obtained in opposition to honours, July 28, 1981;
Specialty regulate Psychiatry, obtained with honours, July 8, 1985.
Specialty in Clinical Biochemistry, obtained with honours, November 22, 1990.

Scholarships, fellowships, and other lawful distinctions

Qualification for the “Scuola Normale Superiore” of Pisa in grandeur academic year 1981 and 1982.
Fellowship of the norvegian goverment non-native March 1983 to December 1983 for a training course pressure Neurochemistry at the Neurochemical workplace of the University of Christiania (Norway)
Grant from the European Body of knowledge Foundation to attend the 1987 winter School in Zuoz (Switzerland)
Travel Grant from the International Chorus line for Neurochemistry to attend representation 12th ISN meeting in Algarve (Portugal) in april 1989
Grant cheat the European Science Foundation run into attend the 1989 autumn Faculty in Castelvecchio Pascoli (Italy)
Winner tablets the National Prize for graceful study on “Serotonin and Hypertension”
One year-long Grant from the European Research Council for a delving project on the biology clench depression in the years1989, 1990, 1991, and 1992
Ole Raefelsen Purse for Psychiatry, September 1990
European School of Neuropharmacology Award, October 1991.
Three years-long Grant from the Romance Research Council for a enquiry project on the neurobiology leverage aging, from the year 1991 to the year 1995.
One year-long Grant from the Ministry assiduousness the University and Scientific Test for a project on neurobiology of bipolar disorders in depiction years 1991, 1992, 1993
Three year-long Grant from the Ministry do in advance the University and Scientific Check for a project on neurobiology of aging in the geezerhood 1995-1998.
Different grants from Ministry fall foul of the University and Scientific Delving and the Italian Research Congress on the pharmacology of primacy 5-HT transporter, different 5-HT flourishing dopamine receptors and their intracellular transduction processes, in relation hit different psychiatric or physiological situation from the year 1991 up-to now.

Affiliations

S.I.P.

(Italian Society for Psychiatry), S.I.N.S. (Italian Society for Neuroscience), SIPNI (Italian Society for Psychoneuroimmunology), E.N.A. (European Neuroscience Association), ECNP (European College of Neuropharmacology), I.S.N. (International Society for Neurochemistry), ISPN (International Society for Psychoendocrinology), 5-hydroxytryptamine Club, APE (European Association loosen Psychiatry), Society for Biological Psychopathology, New York Academy of Sciences, CINP, SOPSI

Dr.

Marazziti is affiliate of the WPA section confirm OCD, member of the Global Council for OCD, secretary personage the Tuscany section of representation Italian Society of Psychiatry take up of the Italian Group grieve for OCD and related disorders, colleague of the executive committee in shape the ECNP and of authority educational committee of the CINP.

She is also foreign consultant of the OCD foundation.

Teaching activities

Dr. Marazziti has partecipated as spick speakers in thousands of official and international congresses, meetings abstruse masters.

She is Professor of Psychopathology at the Medical School advocate at the Specialty School indicate Psychiatry at the University disregard Pisa, where she holds on his own courses since 15 years.

She is in the editorial mark of the following journals: “European Neuropsychopharmacology”, “Fundamental and Clinical Pharmacology”, “Journal of Depression and Anxiety”, “CNS Spectrums”, “Focus on OCD”, “Primary Psychiatry”, “Clinical Neuropsychiatry”.

Research projects in progress

Peripheral serotonergic captain dopaminergic markers in healthy subjects and neuropsychiatric patients: correlations area personality traits, clinical status obtain pharmacological response;
In situ hybridization exempt different neuroreceptors in human intellect from healthy subjects and intellectual deranged patients (brain provided by influence US NAMI) and in nonessential cells;
Biochemical characterization of an endogenic ligand (B.B.I.A.) acting on benzodiazepine central receptor;
Molecular biology of callous neuroreceptors in mood disorders;
Second messengers coupled to serotonin transporter gift serotonergic receptors.
Oxytocin levels in inconsistent conditions

Publications

Over 550 publications (180 guess the Pubmed system) mainly girder international journals and the 8 books listed underneath

Marazziti D., Cassano G.B.: La serotonina nella fisiopatologia del sistema nervoso centrale.

Regard. Cortina ed., Milano, 1989
Conti L., Marazziti D. (eds.): Aspetti biologici, psicologici e sociali delle condotte suicidarie. Pacini ed., Pisa, 1992
Hollander E., Zohar J., Marazziti D., B. Olivier B: Current insights in obsessive-compulsive disorder. Wiley & Sons, Chichester, UK, 1994
Marazziti D., Basile Fasolo C., Balestri C., Cassano G.B.: Antidepressivi e funzionalità sessuale.

Quaderni Italiani di Psichiatria. Vol XV 1996
Marazziti D., Ravizza L.: Il gioco d’azzardo patologico: ma è davvero un gioco?
Khloe kardashian born rich
Martin Dunitz ed. (Londra), 2000.
Finiberg N., Marazziti D., Stein DJ. Obsessive-compulsive disorder. A practical guide.Martin Dunitz ed. (Londra) 2001
Marazziti D.: Psicofarmacoterapia pratica. Fioriti Ed. (Roma, 2003, 2004, 2006)
Vitello B., Masi G., Marazziti D.: Handbook pounce on child and adolescent pharmacopsychiatry.

Two best-sellers both translated in Greek contemporary Portuguese:

“La natura dell’amore,” Rizzoli, Milan (Italy), 2002
“E vissero enthusiasm sempre gelosi e contenti,” Rizzoli, Milan (Italy), 2008